Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Oncology Biomarker Development, Genentech Inc, Basel, Switzerland. Department of Translational Genomics, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, CA, USA. Division of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, USA. Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. lenz@usc.edu.